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It was the exploration of melatonin synthesis in endocrine body organs, namely the pineal gland, neural frameworks, and immunocompetent cells such as T lymphocytes, NK cells, as well as mast cells that triggered the new techniques to the unifield signal guideline of homeostasis, which, at the turn of the 21st century, bring about the development of a new essential biomedical discipline - neuroimmunoendocrinology.
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